Title : Development and validation of a HPLC electrochemical detection method to measure COMT activity as a tool in drug development.

Pub. Date : 2019 May 1

PMID : 31109396






2 Functional Relationships(s)
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1 The known selective COMT inhibitor entacapone was used as test inhibitor. entacapone catechol-O-methyltransferase Rattus norvegicus
2 The results confirmed the ability of entacapone to inhibit COMT activity by decreasing the production of all the metabolites of norepinephrine. entacapone catechol-O-methyltransferase Rattus norvegicus