Title : Vitamin E analogues differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic acid cytotoxicity.

Pub. Date : 2019 Jul 1

PMID : 31102695






2 Functional Relationships(s)
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1 In the present study, the hypothesis to be tested is that tocotrienols inhibit CYP3A-catalyzed lithocholic acid 3-oxidation, thereby influencing lithocholic acid cytotoxicity. Tocotrienols cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Compared to lithocholic acid 3-oxidation, CYP3A-catalyzed testosterone 6beta-hydroxylation was inhibited to a lesser extent by alpha-tocotrienol, gamma-tocotrienol, delta-tocotrienol, and a tocotrienol-rich vitamin E mixture. Tocotrienols cytochrome P450 family 3 subfamily A member 4 Homo sapiens