Pub. Date : 2019 Aug 1
PMID : 31102529
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: To test whether physiological concentrations of N-acetylcysteine, a clinically safe antioxidant drug currently used in human therapy, is able to reduce ROS production, SOS induction and mutagenesis in ciprofloxacin-treated bacteria without affecting antibiotic activity. | Acetylcysteine | xylosyltransferase 2 | Homo sapiens |
| 2 | RESULTS: Treatment with N-acetylcysteine reduced intracellular ROS levels (by ~40%), as well as SOS induction (by up to 75%) and bacterial filamentation caused by subinhibitory concentrations of ciprofloxacin, without affecting ciprofloxacin antibacterial activity. | Acetylcysteine | xylosyltransferase 2 | Homo sapiens |
| 3 | Remarkably, N-acetylcysteine completely abolished SOS-mediated mutagenesis. | Acetylcysteine | xylosyltransferase 2 | Homo sapiens |
| 4 | CONCLUSIONS: Collectively, our data strongly support the notion that ROS are a key factor in antibiotic-induced SOS mutagenesis and open the possibility of using N-acetylcysteine in combination with antibiotic therapy to hinder the development of antibiotic resistance. | Acetylcysteine | xylosyltransferase 2 | Homo sapiens |