Title : Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity.

Pub. Date : 2019 May 28

PMID : 31097581






5 Functional Relationships(s)
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1 Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity. Vitamin A retinoic acid receptor beta Homo sapiens
2 Here we show that epithelial cell expression of the transcription factor retinoic acid receptor beta (RARbeta) is essential for vitamin A-dependent intestinal immunity. Vitamin A retinoic acid receptor beta Homo sapiens
3 Here we show that epithelial cell expression of the transcription factor retinoic acid receptor beta (RARbeta) is essential for vitamin A-dependent intestinal immunity. Vitamin A retinoic acid receptor beta Homo sapiens
4 Epithelial RARbeta activated vitamin A-dependent expression of serum amyloid A (SAA) proteins by binding directly to Saa promoters. Vitamin A retinoic acid receptor beta Homo sapiens
5 More broadly, epithelial RARbeta was required for the development of key vitamin A-dependent adaptive immune responses, including CD4+ T-cell homing to the intestine and the development of IgA-producing intestinal B cells. Vitamin A retinoic acid receptor beta Homo sapiens