Title : Diallyl Trisulfide Enhances Benzo[a]pyrene-induced CYP1A1 Expression and Metabolic Activation in Hepatic HepG2 Cells.

Pub. Date : 2019 May

PMID : 31092429






6 Functional Relationships(s)
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1 BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR). Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
2 BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR). Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
3 BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR). Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
4 BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR). Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
5 DATS enhanced BaP-induced AHR recruitment and histone H3 acetylation on the CYP1A1 promoter. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
6 CONCLUSION: DATS combined treatment enhances BaP metabolic activation through an AHR-modulating mechanism. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens