Title : Decrement in Cellular Iron and Reactive Oxygen Species, and Improvement of Insulin Secretion in a Pancreatic Cell Line Using Green Tea Extract.

Pub. Date : 2019 May/Jun

PMID : 31091209






4 Functional Relationships(s)
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1 OBJECTIVES: We have investigated the efficacy of mono- and combined therapy with green tea extract (GTE) in mobilizing redox iron, scavenging reactive oxygen species (ROS), and improving insulin production in iron-loaded pancreatic cells. epigallocatechin gallate insulin Homo sapiens
2 Importantly, secretory insulin levels were increased nearly 2.5-fold with 2.29 mug of EGCG equivalent GTE, indicating a recovery in insulin production. epigallocatechin gallate insulin Homo sapiens
3 Importantly, secretory insulin levels were increased nearly 2.5-fold with 2.29 mug of EGCG equivalent GTE, indicating a recovery in insulin production. epigallocatechin gallate insulin Homo sapiens
4 CONCLUSIONS: Green tea EGCG ameliorated oxidative damage of iron-loaded beta-cells by removing redox iron and free radicals and attenuating insulin production. epigallocatechin gallate insulin Homo sapiens