Title : HIF Inactivation of p53 in Ovarian Cancer Can Be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity.

Pub. Date : 2019 Aug

PMID : 31088908






1 Functional Relationships(s)
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1 TPT-mediated downregulation of HIF1alpha in hypoxic cells required TOPO1 resident on HIF1alpha mRNA, restored p53 transcriptional activity, downregulated ABCB1/ABCB5 cell surface expression, and reversed hypoxia-related cisplatin and paclitaxel resistance. Topotecan ATP binding cassette subfamily B member 1 Homo sapiens