Title : Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells.

Pub. Date : 2019 Jul

PMID : 31082618






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Metformin inhibits beta-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells. Metformin AKT serine/threonine kinase 1 Homo sapiens
2 Here we report that a non-canonical Ser552 phosphorylation in beta-catenin, which promotes its nuclear accumulation and transcriptional activity, is blocked by metformin via AMPK-mediated PI3K/Akt signaling inhibition. Metformin AKT serine/threonine kinase 1 Homo sapiens