Pub. Date : 2019 Dec
PMID : 31079497
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of Srxn1 on growth and Notch signalling of astrocyte induced by hydrogen peroxide. | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the effect of Sulfiredoxin-1 (Srxn1) on astrocyte injury induced by hydrogen peroxide (H2O2). | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 3 | OBJECTIVE: To investigate the effect of Sulfiredoxin-1 (Srxn1) on astrocyte injury induced by hydrogen peroxide (H2O2). | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 4 | OBJECTIVE: To investigate the effect of Sulfiredoxin-1 (Srxn1) on astrocyte injury induced by hydrogen peroxide (H2O2). | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 5 | OBJECTIVE: To investigate the effect of Sulfiredoxin-1 (Srxn1) on astrocyte injury induced by hydrogen peroxide (H2O2). | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 6 | METHODS: Observing the changes of H2O2 on contents of lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and apoptosis after transfected Srxn1 siRNA into astrocytes. | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 7 | RESULTS: Knockdown of Srxn1 could promote the secretion of LDH and MDA, decrease the activity of SOD and aggravate apoptosis of astrocytes induced by H2O2. | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 8 | The results of Western blot, ELISA assay and flow cytometry indicated that activation of the Notch signalling pathway attenuated the effect of Srxn1 on H2O2-induced oxidative damage and apoptosis of astrocytes. | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |
| 9 | CONCLUSION: Srxn1 may protect astrocytes from oxidative stress injury induced by H2O2 by activation of Notch signalling pathway. | Hydrogen Peroxide | sulfiredoxin 1 | Homo sapiens |