Pub. Date : 2019 Aug 1
PMID : 31078568
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Cisplatin-induced nitration and degradation of LMO4 could destabilize this protein complex, which in turn could compromise the downstream STAT3-mediated cellular defense mechanism. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | Here, we investigated the link between cisplatin-induced nitrative stress and STAT3-mediated apoptosis by using organ of Corti cell cultures. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | Immunoblotting and immunostaining indicated that cisplatin treatment decreased the expression levels, phosphorylation, and nuclear localization of STAT3 in UB/OC1 cells. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |
| 5 | Inhibition of nitration by SRI110 co-treatment prevented cisplatin-induced inactivation of STAT3 and promoted its nuclear localization. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |
| 6 | SRI110 co-treatment reversed the cisplatin-induced changes in the expression levels of Bcl2l1, Ccnd1, Jak2, Jak3, and Src and significantly attenuated the changes in the expression levels of Cdkn1a, Egfr, Fas, Il6st, Jak1, Stat3, and Tyk2. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |
| 7 | Collectively, these results suggest that the inhibition of cisplatin-induced nitration prevents the inactivation of STAT3, which in turn enables the transcription of anti-apoptotic genes and thereby helps to mitigate cisplatin-induced toxicity. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |
| 8 | Collectively, these results suggest that the inhibition of cisplatin-induced nitration prevents the inactivation of STAT3, which in turn enables the transcription of anti-apoptotic genes and thereby helps to mitigate cisplatin-induced toxicity. | Cisplatin | signal transducer and activator of transcription 3 | Mus musculus |