Pub. Date : 2019 Sep
PMID : 31069623
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, in MPP+-treated BV-2 cells and primary microglia, FTY720 treatment significantly attenuated the increases in the phosphorylation of PI3K/AKT/GSK-3beta, reduced ROS generation and p65 activation, and also inhibited the activation of NLRP3 inflammasome and caspase-1. | Fingolimod Hydrochloride | glycogen synthase kinase 3 alpha | Mus musculus |
| 2 | Graphical Abstract FTY720 may reduce ROS production by inhibiting the PI3K/AKT/GSK-3beta signaling pathway, while at the same time reducing p65 phosphorylation, thus decreasing NLRP3 inflammasome activation through these two pathways, ultimately reducing microglia activation-induced neuronal damage. | Fingolimod Hydrochloride | glycogen synthase kinase 3 alpha | Mus musculus |