Title : Vorapaxar stabilizes permeability of the endothelial barrier under cholesterol stimulation via the AKT/JNK and NF‑κB signaling pathways.

Pub. Date : 2019 Jun

PMID : 31059055






1 Functional Relationships(s)
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1 We also found that vorapaxar could reduce the damage of DNA caused by cholesterol stimulation and regulate the cell cycle via the AKT/JNK signaling pathway and its downstream molecules glycogen synthase kinase 3beta (GSK-3beta) and connexin 43, maintaining the integrity of the endothelial barrier and proliferation of endothelial cells, serving a protective role in endothelial cells. vorapaxar gap junction protein alpha 1 Homo sapiens