Title : NADPH Oxidase Isoforms Are Involved in Glucocorticoid-Induced Preosteoblast Apoptosis.

Pub. Date : 2019

PMID : 31049140






2 Functional Relationships(s)
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1 Small interfering RNAs (siRNAs) were used to confirm the role of NOX1 and NOX4 in ROS generation. Reactive Oxygen Species NADPH oxidase 4 Mus musculus
2 Altogether, NOX1- and NOX4-derived ROS plays a pivotal role in high-dose dexamethasone-induced preosteoblast apoptosis by increasing phosphorylated ASK1 and p38 and may be an important mechanism in steroid-induced avascular necrosis of the femoral head (SANFH). Reactive Oxygen Species NADPH oxidase 4 Mus musculus