Title : Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-β.

Pub. Date : 2019 May 21

PMID : 31042246






2 Functional Relationships(s)
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1 Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Abeta (phen, 1, and 2), or both (3). 1,10-phenanthroline amyloid beta precursor protein Homo sapiens
2 Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Abeta (phen, 1, and 2), or both (3). 1,10-phenanthroline amyloid beta precursor protein Homo sapiens