Title : Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Pub. Date : 2019 May 13

PMID : 31031016






2 Functional Relationships(s)
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1 Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3beta-MCL-1 Axis. Metformin MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Synergistic anti-neoplastic effects of the metformin/hypoglycemia combination were mediated by glycogen synthase kinase 3beta (GSK3beta) activation downstream of PP2A, leading to a decline in the pro-survival protein MCL-1, and cell death. Metformin MCL1 apoptosis regulator, BCL2 family member Homo sapiens