Title : Solubility and bioavailability enhancement study of lopinavir solid dispersion matrixed with a polymeric surfactant - Soluplus.

Pub. Date : 2019 Jun 15

PMID : 31028820






1 Functional Relationships(s)
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1 Herein, Soluplus matrixed extrudate improved the LPV bioavailability through three mechanisms: H-bond with LPV, micelle formation in water and P-gp inhibition in vivo. Lopinavir ATP binding cassette subfamily B member 1 Homo sapiens