Pub. Date : 2019 Aug 15
PMID : 31026457
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/beta-catenin signaling pathway. | gastrodin | catenin beta 1 | Rattus norvegicus |
| 2 | In addition, the present results have shown that Gastrodin inhibited LPS-induced phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser 9 and beta-catenin activity. | gastrodin | catenin beta 1 | Rattus norvegicus |
| 3 | Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia. | gastrodin | catenin beta 1 | Rattus norvegicus |
| 4 | Taken together, the present results suggested that Gastrodin mediated anti-inflammatory and anti-proliferation effects in activated microglia by modulating the Wnt/beta-catenin signaling pathway. | gastrodin | catenin beta 1 | Rattus norvegicus |