Pub. Date : 2019 Apr 25
PMID : 31023247
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells. | salinomycin | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 | Homo sapiens |
| 2 | We also found that salinomycin could trigger ER stress, which might be related to ATP2A3-mediated Ca2+ release in PC-3 cells. | salinomycin | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 | Homo sapiens |
| 3 | CONCLUSION: This study demonstrates that ATP2A3 might be one of the potential targets for salinomycin, which can inhibit Ca2+ release and trigger ER stress to exert anti-cancer effects. | salinomycin | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 | Homo sapiens |