Title : Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis.

Pub. Date : 2019 Jun

PMID : 31014753






1 Functional Relationships(s)
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Protein Name
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1 VE-822 and AZD1775 decreased the protein levels of ribonucleotide reductase M1 (RRM1) and M2 (RRM2) subunits, key enzymes in the synthesis of deoxyribonucleoside triphosphate, which increased DNA replication stress. deoxyribonucleoside triphosphate ribonucleotide reductase regulatory subunit M2 Homo sapiens