Title : SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4.

Pub. Date : 2019 Aug

PMID : 31011814






1 Functional Relationships(s)
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1 In addition, SN-38 abrogated LPS-dependent neutrophil migration and reduced TNF-alpha, IL-6, and keratinocyte chemoattractant levels in the air-pouch model, but failed to inhibit zymosan (a TLR2 agonist)-induced cell migration. Irinotecan interleukin 6 Mus musculus