Title : Cholix toxin, an eukaryotic elongation factor 2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.

Pub. Date : 2019 Aug

PMID : 31009148






4 Functional Relationships(s)
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1 Furthermore, Cholix induced activation of Rho-associated coiled coil-containing protein kinase 1 (ROCK1), which was enhanced in PHB-knockdown cells, followed by actin filament depolymerisation and accumulation of tubulin in the blebbing cells. cholix Rho associated coiled-coil containing protein kinase 1 Homo sapiens
2 Furthermore, Cholix induced activation of Rho-associated coiled coil-containing protein kinase 1 (ROCK1), which was enhanced in PHB-knockdown cells, followed by actin filament depolymerisation and accumulation of tubulin in the blebbing cells. cholix Rho associated coiled-coil containing protein kinase 1 Homo sapiens
3 Inhibition of ROCK1 by siRNA or its inhibitor suppressed Cholix-induced PARP cleavage and reactive oxygen species generation. cholix Rho associated coiled-coil containing protein kinase 1 Homo sapiens
4 Our findings identify PHB as a new protein that interacts with Cholix and is involved in Cholix-induced mitochondrial dysfunction and cytoskeletal rearrangement by ROCK1 activation during apoptosis. cholix Rho associated coiled-coil containing protein kinase 1 Homo sapiens