Protein Name Rho associated coiled-coil containing protein kinase 1
Organism Homo sapiens
Gene ID 6093
Gene Symbol

ROCK1

UniProt Q13464 (ROCK1_HUMAN)
Relationships Total Number of functionally related compound(s) : 233
Total Number of Articles : 284
Description

Rho associated coiled-coil containing protein kinase 1

Gene Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]

synonyms
  • rho-associated protein kinase 1
  • p160 ROCK-1
  • renal carcinoma antigen NY-REN-35
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Properties