Pub. Date : 2019 Apr 25
PMID : 31008484
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EP1/EP3 agonist 17-phenyl-trinor-PGE2 stimulated IL-6 and TNFalpha whilst suppressing IL-1beta and CXCL8 output. | 17-phenyltrinorprostaglandin E2 | interleukin 6 | Homo sapiens |
| 2 | The stimulatory effects of 17-phenyl-trinor-PGE2 on IL-6 and TNFalpha were remained whereas the inhibitory effects of 17-phenyl-trinor-PGE2 on IL-1beta secretion was blocked in the cells with EP1 knockdown. | 17-phenyltrinorprostaglandin E2 | interleukin 6 | Homo sapiens |
| 3 | PI3K inhibitor LY294002 and P38 inhibitor SB202190 blocked 17-phenyl-trinor-PGE2-induced IL-1beta and IL-6 output, respectively. | 17-phenyltrinorprostaglandin E2 | interleukin 6 | Homo sapiens |