Title : Multispecies study: low-dose tributyltin impairs ovarian theca cell cholesterol homeostasis through the RXR pathway in five mammalian species including humans.

Pub. Date : 2019 Jun

PMID : 31006824






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TBT, at an environmentally relevant dose, stimulates theca cell cholesterol extracellular efflux via the RXR pathway, triggers a compensatory upregulation of StAR that regulates cholesterol transfer into the mitochondria and SREBF1 for de novo cholesterol synthesis. Cholesterol steroidogenic acute regulatory protein Homo sapiens
2 TBT, at an environmentally relevant dose, stimulates theca cell cholesterol extracellular efflux via the RXR pathway, triggers a compensatory upregulation of StAR that regulates cholesterol transfer into the mitochondria and SREBF1 for de novo cholesterol synthesis. Cholesterol steroidogenic acute regulatory protein Homo sapiens