Protein Name steroidogenic acute regulatory protein
Organism Homo sapiens
Gene ID 6770
Gene Symbol

STAR

UniProt P49675 (STAR_HUMAN), Q6IBK0 (Q6IBK0_HUMAN)
Relationships Total Number of functionally related compound(s) : 429
Total Number of Articles : 574
Description

steroidogenic acute regulatory protein

Gene Summary

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]

synonyms
  • steroidogenic acute regulatory protein, mitochondrial
  • START domain containing 1
  • START domain-containing protein 1
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Properties