Title : A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728.

Pub. Date : 1987 Feb 5

PMID : 3100536






4 Functional Relationships(s)
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1 We have now established that the fragment extends to residue Lys-728 and demonstrate here that a high affinity heparin-binding domain of vWF also lies within this region and in close proximity to that for GPIb. Heparin von Willebrand factor Homo sapiens
2 We have used an assay employing heparin coupled to Sepharose CL-6B to show that 125I-vWF binds to heparin in a time-dependent, saturable, and reversible manner. Heparin von Willebrand factor Homo sapiens
3 We have used an assay employing heparin coupled to Sepharose CL-6B to show that 125I-vWF binds to heparin in a time-dependent, saturable, and reversible manner. Heparin von Willebrand factor Homo sapiens
4 Twelve monoclonal antibodies to the 52/48-kDa fragment were evaluated for their ability to block binding of 125I-vWF to heparin. Heparin von Willebrand factor Homo sapiens