Title : Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2.

Pub. Date : 2019 Jun 1

PMID : 31002870






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The results showed that metformin pretreatment increased the phosphorylation of HDAC5 at serine 498, leading to the upregulation of KLF2, and eliminated lipopolysaccharide (LPS) and tumor necrosis factor (TNF )-induced upregulation of vascular cell adhesion molecule 1 (VCAM1). Metformin tumor necrosis factor Mus musculus
2 The results showed that metformin pretreatment increased the phosphorylation of HDAC5 at serine 498, leading to the upregulation of KLF2, and eliminated lipopolysaccharide (LPS) and tumor necrosis factor (TNF )-induced upregulation of vascular cell adhesion molecule 1 (VCAM1). Metformin tumor necrosis factor Mus musculus