Title : Possible Role of Cyclic AMP Response Element Binding/Brain-Derived Neurotrophic Factor Signaling Pathway in Mediating the Pharmacological Effects of Duloxetine against Methamphetamine Use-Induced Cognitive Impairment and Withdrawal-Induced Anxiety and Depression in Rats.

Pub. Date : 2019

PMID : 30993081






3 Functional Relationships(s)
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1 Possible Role of Cyclic AMP Response Element Binding/Brain-Derived Neurotrophic Factor Signaling Pathway in Mediating the Pharmacological Effects of Duloxetine against Methamphetamine Use-Induced Cognitive Impairment and Withdrawal-Induced Anxiety and Depression in Rats. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus
2 In both experiments, duloxetine activated cAMP, CREB, and BDNF proteins" expression in methamphetamine-treated rats. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus
3 Conclusions: Duloxetine can protect the brain against methamphetamine withdrawal-induced mood and motor disturbances and can also inhibit methamphetamine-induced cognitive impairment, possibly via cAMP/CREB/BDNF signaling pathway. Duloxetine Hydrochloride brain-derived neurotrophic factor Rattus norvegicus