Title : Extracellular HMGB1 prevents necroptosis in acute myeloid leukemia cells.

Pub. Date : 2019 Apr

PMID : 30970518






1 Functional Relationships(s)
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1 In two AML cell lines and primary AML cells from two patients, etoposide induced necroptosis via cIAP1/2 degradation when caspase activity was inhibited by Z-VAD-fmk, but treatment with extracellular HMGB1 prevented this necroptosis. Etoposide high mobility group box 1 Homo sapiens