Title : The absorption of apolipoprotein E by damaged neurons facilitates neuronal repair.

Pub. Date : 2019 Jun

PMID : 30958617






6 Functional Relationships(s)
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1 Furthermore, we found that mechanically injured si-apoE neurons could absorb the secreted apoE from the oligodendrocyte medium of the injured si-apoE-neuron, along with increasing of p-P38 expression at 24 h. The p38 MAPK inhibitor BIRB 796 almost did not affect the apoE expression at 24 h, but significantly reduced the p-P38 level at 24 and 72 h in injured si-apoE neurons cultured with oligodendrocyte medium of the injured si-apoE-neurons. doramapimod apolipoprotein E Homo sapiens
2 Furthermore, we found that mechanically injured si-apoE neurons could absorb the secreted apoE from the oligodendrocyte medium of the injured si-apoE-neuron, along with increasing of p-P38 expression at 24 h. The p38 MAPK inhibitor BIRB 796 almost did not affect the apoE expression at 24 h, but significantly reduced the p-P38 level at 24 and 72 h in injured si-apoE neurons cultured with oligodendrocyte medium of the injured si-apoE-neurons. doramapimod apolipoprotein E Homo sapiens
3 Furthermore, we found that mechanically injured si-apoE neurons could absorb the secreted apoE from the oligodendrocyte medium of the injured si-apoE-neuron, along with increasing of p-P38 expression at 24 h. The p38 MAPK inhibitor BIRB 796 almost did not affect the apoE expression at 24 h, but significantly reduced the p-P38 level at 24 and 72 h in injured si-apoE neurons cultured with oligodendrocyte medium of the injured si-apoE-neurons. doramapimod apolipoprotein E Homo sapiens
4 Furthermore, we found that mechanically injured si-apoE neurons could absorb the secreted apoE from the oligodendrocyte medium of the injured si-apoE-neuron, along with increasing of p-P38 expression at 24 h. The p38 MAPK inhibitor BIRB 796 almost did not affect the apoE expression at 24 h, but significantly reduced the p-P38 level at 24 and 72 h in injured si-apoE neurons cultured with oligodendrocyte medium of the injured si-apoE-neurons. doramapimod apolipoprotein E Homo sapiens
5 Furthermore, we found that mechanically injured si-apoE neurons could absorb the secreted apoE from the oligodendrocyte medium of the injured si-apoE-neuron, along with increasing of p-P38 expression at 24 h. The p38 MAPK inhibitor BIRB 796 almost did not affect the apoE expression at 24 h, but significantly reduced the p-P38 level at 24 and 72 h in injured si-apoE neurons cultured with oligodendrocyte medium of the injured si-apoE-neurons. doramapimod apolipoprotein E Homo sapiens
6 Furthermore, we found that mechanically injured si-apoE neurons could absorb the secreted apoE from the oligodendrocyte medium of the injured si-apoE-neuron, along with increasing of p-P38 expression at 24 h. The p38 MAPK inhibitor BIRB 796 almost did not affect the apoE expression at 24 h, but significantly reduced the p-P38 level at 24 and 72 h in injured si-apoE neurons cultured with oligodendrocyte medium of the injured si-apoE-neurons. doramapimod apolipoprotein E Homo sapiens