Protein Name apolipoprotein E
Organism Homo sapiens
Gene ID 348
Gene Symbol


UniProt P02649 (APOE_HUMAN), A0A0S2Z3D5 (A0A0S2Z3D5_HUMAN)
Relationships Total Number of functionally related compound(s) : 1088
Total Number of Articles : 3332

apolipoprotein E

Gene Summary

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

  • apolipoprotein E
  • apolipoprotein E3
  • AD2
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