Title : Triptolide Suppresses Growth of Breast Cancer by Targeting HMGB1 in Vitro and in Vivo.

Pub. Date : 2019 Jun 1

PMID : 30956264






2 Functional Relationships(s)
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1 Furthermore, downstream correlation factors (Toll-like receptor 4 (TLR4) and phosphorylated-nuclear factor-kappaB (NF-kappaB) p65) of HMGB1 were significantly decreased in vitro after triptolide treatment. triptolide RELA proto-oncogene, NF-kB subunit Homo sapiens
2 Meanwhile, immunohistochemical analyses showed that triptolide treatment significantly decreased the level of cytoplasmic HMGB1 and TLR4 expression, whereas the expression of NF-kappaB p65 was relatively higher in cytoplasm, and conversely lower in nucleus as compared to the control group. triptolide RELA proto-oncogene, NF-kB subunit Homo sapiens