Pub. Date : 2019 Apr
PMID : 30956031
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKA/CREB and P38/MAPK signaling pathways. | fargesin | cAMP responsive element binding protein 1 | Mus musculus |
| 2 | Fargesin also effectively inhibited the activation of PKA/CREB and p38 MAPK as well as their interactions, which in turn is responsible for the expression of MITF and melanogenic enzymes. | fargesin | cAMP responsive element binding protein 1 | Mus musculus |
| 3 | CONCLUSIONS: These results show that fargesin can function as an anti-melanogenic agent, at least in part, by inhibiting PKA/CREB and p38/MAPK signaling pathways. | fargesin | cAMP responsive element binding protein 1 | Mus musculus |