Title : Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis.

Pub. Date : 2019 May 15

PMID : 30951745






3 Functional Relationships(s)
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1 H2 could inhibit the activation of p38 and JNK, suggesting H2 played an active part in resisting renal injury via MAPK. Hydrogen mitogen-activated protein kinase 8 Rattus norvegicus
2 H2 could inhibit the activation of p38 and JNK, suggesting H2 played an active part in resisting renal injury via MAPK. Hydrogen mitogen-activated protein kinase 8 Rattus norvegicus
3 SIGNIFICANCE: Taken together, our study reveals that H2 can ameliorate CIH-induced kidney injury by decreasing endoplasmic reticulum stress and activating autophagy through inhibiting oxidative stress-dependent p38 and JNK MAPK activation. Hydrogen mitogen-activated protein kinase 8 Rattus norvegicus