Title : Bradykinin increases BP in endotoxemic rat: functional and biochemical evidence of angiotensin II AT1 /bradykinin B2 receptor heterodimerization.

Pub. Date : 2019 Jul

PMID : 30945263






2 Functional Relationships(s)
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1 The pressor effect of bradykinin was not prevented by prazosin, an alpha1 -adrenoceptor antagonist, but it was inhibited by the AT1 receptor antagonist losartan or the Rho-kinase inhibitor Y-27632. Losartan angiotensin II receptor, type 1a Rattus norvegicus
2 The presence of AT1 /B2 receptor heterodimers did correlate with the development of losartan-sensitive contractile responses to bradykinin and potentiation of angiotensin II-induced contraction, which was prevented by Hoe-140. Losartan angiotensin II receptor, type 1a Rattus norvegicus