Title : p62 aggregates mediated Caspase 8 activation is responsible for progression of ovarian cancer.

Pub. Date : 2019 Jun

PMID : 30941888






2 Functional Relationships(s)
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1 In vivo experiments suggested that insoluble p62 and ubiquitinated protein accumulation induced by autophagy impairment promoted the activation of Caspase 8 and increased cell sensitivity to cisplatin. Cisplatin sequestosome 1 Homo sapiens
2 Collectively, our study demonstrates that p62 promotes Caspase 8 activation through autophagy flux blockage with cisplatin treatment. Cisplatin sequestosome 1 Homo sapiens