Protein Name sequestosome 1
Organism Homo sapiens
Gene ID 8878
Gene Symbol


UniProt Q13501 (SQSTM_HUMAN)
Relationships Total Number of functionally related compound(s) : 373
Total Number of Articles : 464

sequestosome 1

Gene Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

  • sequestosome-1
  • EBI3-associated protein of 60 kDa
  • EBI3-associated protein p60
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