Pub. Date : 2019 Jun
PMID : 30930217
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression and regulation of GnRHR2 gene and testosterone secretion mediated by GnRH2 and GnRHR2 within porcine testes. | Testosterone | gonadotropin releasing hormone 2 | Homo sapiens |
| 2 | However, little is known concerning the effect of transcription factor steroidogenic factor1 (SF-1) regulation on porcine GnRHR2 gene expression and GnRH2 regulation mechanism in testosterone secretion through GnRHR2. | Testosterone | gonadotropin releasing hormone 2 | Homo sapiens |
| 3 | Meanwhile, our study also demonstrated GnRH2 treatment promoted the expression of SF-1 and steroidogenic acute regulatory protein (StAR), and that this treatment stimulated cAMP responsive element binding protein (CREB) phosphorylation, regulated the expression of GnRHR2, especially that of GnRHR2-X1, and promoted testosterone secretion in porcine Leydig cells. | Testosterone | gonadotropin releasing hormone 2 | Homo sapiens |
| 4 | We speculated that testosterone secretion mediated by GnRH2 and GnRHR2 (mainly GnRHR2-X1) was regulated by phosphorylated CREB interacting with SF-1 to control StAR expression. | Testosterone | gonadotropin releasing hormone 2 | Homo sapiens |
| 5 | This study also explores the regulation mechanism of testosterone secretion mediated by GnRH2 and GnRHR2 in porcine Leydig cells. | Testosterone | gonadotropin releasing hormone 2 | Homo sapiens |