PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30930217-0 2019 Expression and regulation of GnRHR2 gene and testosterone secretion mediated by GnRH2 and GnRHR2 within porcine testes. Testosterone 45-57 gonadotropin releasing hormone 2 Homo sapiens 80-85 30930217-2 2019 However, little is known concerning the effect of transcription factor steroidogenic factor1 (SF-1) regulation on porcine GnRHR2 gene expression and GnRH2 regulation mechanism in testosterone secretion through GnRHR2. Testosterone 179-191 gonadotropin releasing hormone 2 Homo sapiens 149-154 30930217-9 2019 Meanwhile, our study also demonstrated GnRH2 treatment promoted the expression of SF-1 and steroidogenic acute regulatory protein (StAR), and that this treatment stimulated cAMP responsive element binding protein (CREB) phosphorylation, regulated the expression of GnRHR2, especially that of GnRHR2-X1, and promoted testosterone secretion in porcine Leydig cells. Testosterone 316-328 gonadotropin releasing hormone 2 Homo sapiens 39-44 30930217-10 2019 We speculated that testosterone secretion mediated by GnRH2 and GnRHR2 (mainly GnRHR2-X1) was regulated by phosphorylated CREB interacting with SF-1 to control StAR expression. Testosterone 19-31 gonadotropin releasing hormone 2 Homo sapiens 54-59 30930217-12 2019 This study also explores the regulation mechanism of testosterone secretion mediated by GnRH2 and GnRHR2 in porcine Leydig cells. Testosterone 53-65 gonadotropin releasing hormone 2 Homo sapiens 88-93