Pub. Date : 2019 May 15
PMID : 30926247
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety. | benzimidazole | diacylglycerol O-acyltransferase 1 | Mus musculus |
| 2 | Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition comparable to the corresponding parent compounds. | benzimidazole | diacylglycerol O-acyltransferase 1 | Mus musculus |
| 3 | Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition comparable to the corresponding parent compounds. | benzimidazole | diacylglycerol O-acyltransferase 1 | Mus musculus |
| 4 | In this report, we describe the design, synthesis and profiling of benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety. | benzimidazole | diacylglycerol O-acyltransferase 1 | Mus musculus |