Title : Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

Pub. Date : 2019 Jun 20

PMID : 30905681






1 Functional Relationships(s)
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1 YKL-5-124 causes arrest at the G1/S transition and inhibition of E2F-driven gene expression; these effects are rescued by a CDK7 mutant unable to covalently engage YKL-5-124, demonstrating on-target specificity. YKL-5-124 cyclin dependent kinase 7 Homo sapiens