Title : Amyloid-beta induced paralysis is reduced by cholecalciferol through inhibition of the steroid-signaling pathway in an Alzheimer model of Caenorhabditis elegans.

Pub. Date : 2021 Feb

PMID : 30905309






4 Functional Relationships(s)
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Protein Name
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1 Functional DAF-16 proved to be crucial for the effects of cholecalciferol and DAF-16 nuclear translocation was increased by cholecalciferol and also RNAi versus nhr-8, daf-36, daf-9 or daf-12 with no additive or synergistic effects. Cholecalciferol Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
2 Functional DAF-16 proved to be crucial for the effects of cholecalciferol and DAF-16 nuclear translocation was increased by cholecalciferol and also RNAi versus nhr-8, daf-36, daf-9 or daf-12 with no additive or synergistic effects. Cholecalciferol Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
3 Functional DAF-16 proved to be crucial for the effects of cholecalciferol and DAF-16 nuclear translocation was increased by cholecalciferol and also RNAi versus nhr-8, daf-36, daf-9 or daf-12 with no additive or synergistic effects. Cholecalciferol Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans
4 CONCLUSIONS: Our results suggest, that cholecalciferol inhibits Abeta-induced paralysis in C. elegans through inhibition of steroid-signaling and the concomitant nuclear translocation of DAF-16. Cholecalciferol Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans