Title : Metformin and Breast Cancer: Molecular Targets.

Pub. Date : 2019 Jun

PMID : 30903363






1 Functional Relationships(s)
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1 The major molecular targets of metformin include complex I of the mitochondrial electron transport chain, adenosine monophosphate (AMP)-activated protein kinase (AMPK), and mechanistic target of rapamycin complex 1 (mTORC1), but AMPK-independent effects of metformin have also been described. Metformin CREB regulated transcription coactivator 1 Mus musculus