Pub. Date : 2020 Jan
PMID : 30898012
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that pharmacological activation of PPARA by the PPARA agonists gemfibrozil and Wy14643 induces autophagy in human microglia (HM) cells and U251 human glioma cells stably expressing the human APP (amyloid beta precursor protein) mutant (APP-p.M671L) and this effect is PPARA-dependent. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 2 | We found that pharmacological activation of PPARA by the PPARA agonists gemfibrozil and Wy14643 induces autophagy in human microglia (HM) cells and U251 human glioma cells stably expressing the human APP (amyloid beta precursor protein) mutant (APP-p.M671L) and this effect is PPARA-dependent. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 3 | We found that pharmacological activation of PPARA by the PPARA agonists gemfibrozil and Wy14643 induces autophagy in human microglia (HM) cells and U251 human glioma cells stably expressing the human APP (amyloid beta precursor protein) mutant (APP-p.M671L) and this effect is PPARA-dependent. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Homo sapiens |
| 4 | These results indicated that PPARA is an important factor regulating autophagy in the clearance of Abeta and suggested gemfibrozil be assessed as a possible treatment for AD. | Gemfibrozil | peroxisome proliferator activated receptor alpha | Homo sapiens |