Title : Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer.

Pub. Date : 2019 Apr

PMID : 30896891






1 Functional Relationships(s)
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1 In this study, the anti-infective drug nitroxoline (NXQ) was screened out to effectively inhibit cell survival of small-cell lung cancer (SCLC) cells, and induce SCLC cell apoptosis by suppressing antiapoptotic proteins (such as Bcl-2 and MCL1) and upregulating proapoptotic protein Bim. 2-[5-fluoranyl-2-[[3-[methyl(oxidanyl)-$l^{3}-sulfanyl]phenyl]methylcarbamoyl]phenoxy]ethanoic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens