Title : Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via α7nAChR to inhibit inflammation in LPS-stimulated macrophages.

Pub. Date : 2019 Feb

PMID : 30896303






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via alpha7nAChR to inhibit inflammation in LPS-stimulated macrophages. sinomenine toll-like receptor 4 Mus musculus
2 Intracellular-free calcium level was measured by Fluorescent probe fluo-3/AM Results: SIN inhibited the production of TNF-alpha, MCP-1, MIF, and MMP-9, decreased the expression of CD14 and TLR4, and inhibited the release of intracellular-free calcium from intracellular stores in RAW 264.7 cells stimulated by LPS. sinomenine toll-like receptor 4 Mus musculus