Pub. Date : 2019 May
PMID : 30894404
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 2 | G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 3 | G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 4 | Indeed, testosterone stimulates time- and dose-dependent activation of ERK, protein kinase B, and mTORC1 signaling in wild-type PC-3 cells that express endogenous GPRC6AICL3_KGKY In addition, testosterone stimulates GPRC6A-dependent cell proliferation in wild-type PC-3 cells and inhibits autophagy by activating mTORC1 effectors eukaryotic translation initiation factor 4E binding protein 1 and Unc-51 like autophagy activating kinase 1. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 5 | Indeed, testosterone stimulates time- and dose-dependent activation of ERK, protein kinase B, and mTORC1 signaling in wild-type PC-3 cells that express endogenous GPRC6AICL3_KGKY In addition, testosterone stimulates GPRC6A-dependent cell proliferation in wild-type PC-3 cells and inhibits autophagy by activating mTORC1 effectors eukaryotic translation initiation factor 4E binding protein 1 and Unc-51 like autophagy activating kinase 1. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 6 | Testosterone activation of GPRC6A has the obligate requirement for calcium in the incubation media. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 7 | In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 8 | In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 9 | In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |
| 10 | In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. | Testosterone | G protein-coupled receptor class C group 6 member A | Homo sapiens |