PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30894404-0 2019 Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells. Testosterone 22-34 G protein-coupled receptor class C group 6 member A Homo sapiens 6-12 30894404-1 2019 G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression. Testosterone 78-90 G protein-coupled receptor class C group 6 member A Homo sapiens 0-52 30894404-1 2019 G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression. Testosterone 78-90 G protein-coupled receptor class C group 6 member A Homo sapiens 54-60 30894404-8 2019 Indeed, testosterone stimulates time- and dose-dependent activation of ERK, protein kinase B, and mTORC1 signaling in wild-type PC-3 cells that express endogenous GPRC6AICL3_KGKY In addition, testosterone stimulates GPRC6A-dependent cell proliferation in wild-type PC-3 cells and inhibits autophagy by activating mTORC1 effectors eukaryotic translation initiation factor 4E binding protein 1 and Unc-51 like autophagy activating kinase 1. Testosterone 8-20 G protein-coupled receptor class C group 6 member A Homo sapiens 163-169 30894404-8 2019 Indeed, testosterone stimulates time- and dose-dependent activation of ERK, protein kinase B, and mTORC1 signaling in wild-type PC-3 cells that express endogenous GPRC6AICL3_KGKY In addition, testosterone stimulates GPRC6A-dependent cell proliferation in wild-type PC-3 cells and inhibits autophagy by activating mTORC1 effectors eukaryotic translation initiation factor 4E binding protein 1 and Unc-51 like autophagy activating kinase 1. Testosterone 192-204 G protein-coupled receptor class C group 6 member A Homo sapiens 163-169 30894404-9 2019 Testosterone activation of GPRC6A has the obligate requirement for calcium in the incubation media. Testosterone 0-12 G protein-coupled receptor class C group 6 member A Homo sapiens 27-33 30894404-10 2019 In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. Testosterone 54-66 G protein-coupled receptor class C group 6 member A Homo sapiens 16-22 30894404-10 2019 In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. Testosterone 54-66 G protein-coupled receptor class C group 6 member A Homo sapiens 136-142 30894404-10 2019 In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. Testosterone 184-196 G protein-coupled receptor class C group 6 member A Homo sapiens 16-22 30894404-10 2019 In contrast, in GPRC6A-deficient cells, the effect of testosterone to activate downstream signaling is abolished, indicating that human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. Testosterone 184-196 G protein-coupled receptor class C group 6 member A Homo sapiens 136-142