Pub. Date : 2019 Mar 20
PMID : 30894168
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. | Cysteine | vimentin | Homo sapiens |
| 2 | The vimentin target was validated to reveal that ajoene and dansyl-ajoene covalently bind to recombinant vimentin via a disulfide linkage at Cys-328. | Cysteine | vimentin | Homo sapiens |
| 3 | Computational modelling showed Cys-328 to be exposed at the termini of the vimentin tetramer. | Cysteine | vimentin | Homo sapiens |
| 4 | CONCLUSIONS: The garlic-derived phytochemical ajoene targets and covalently modifies vimentin in cancer cells by S-thiolating Cys-328. | Cysteine | vimentin | Homo sapiens |