Pub. Date : 2019 Apr 15
PMID : 30890405
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediated via Nrf2. | euxanthone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Euxanthone up-regulated and activated Nrf2 by repressing Keap1, and increased the expression of its downstream genes HO-1 and NQO-1. | euxanthone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Nrf2 knockdown abrogated the cyto-protective, anti-apoptotic, anti-oxidant and anti-inflammatory effects of euxanthone in ox-LDL-treated HUVECs. | euxanthone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Finally, euxanthone activated Nrf2 via the MAPK pathway and blocking the latter likewise negated the protective effects of euxanthone against cell ox-LDL. | euxanthone | NFE2 like bZIP transcription factor 2 | Homo sapiens |